Antidiabetic Effect of Methanol Extracts of Telfairia Occidentalis and Persea Americana Leaves on Streptozotocin Induced Wistar Rats

This study was carried out to determine the antidiabetic effect of methanol leaf extract of Telfairia occidentalis and Persea americana leaves on Streptozotocin induced diabetic rats. The qualitative phytochemical screening of T. occidentalis and P. americana leaves were carried out using standard methods. Diabetes was induced in the animals by intraperitoneal injection of streptozotocin (50 mg/kg body weight) in 0.1 mol/L citrate buffer (pH 4.5). After 48 hours of the injection, rats that were diabetic (indicated by hyperglycemia) were used for the experiment. Blood samples were collected from the tails of the rats and blood glucose was determined using a glucometer. Thirty rats were divided into six groups of five rats each and treated with different doses of the extracts and compared with 0.25 mg/kg body weight of glibenclamide standard drug. The result showed that; Tannin, phenols and Saponins were found to be present in both T. occidentalis and P. Americana extracts. There was significant increase (p