Effect of Tamsulosin on Fasting Blood Glucose and Plasma Insulin Levels in Normal Wistar Rats

This paper aimed to determine levels of fasting blood sugar and plasma insulin in normal rats administered with tamsulosin. Standard methods and procedures were followed to achieve the objective of this paper. At the 3 rd week of the study, group of rats treated with tamsulosin high dose (40µg/kg) revealed a significant increase in fasting blood glucose (FBG) (P0.05). At the 7th week of the study, only group of rats treated with tamsulosin high dose (40µg/kg) maintained significant higher values (P0.05). At the 8th week, FBG of the group of rats treated with carvedilol (positive control), and groups treated with either tamsulosin low dose (12µg/kg) or tamsulosin high dose (40µg/kg) did not show any significant difference compared to the normal control group. Other inter-group comparisons were not significantly different (P>0.05). For insulin level observations, at the 6th week of the study, groups of rats treated with either carvedilol (positive control), low dose tamsulosin (12µg/kg) or high dose tamsulosin (40µg/kg) revealed a significantly higher elevation (P0.05). At the 8th week, only group of rats treated with carvedilol (positive control) showed a significant higher value (P0.05). The results of the study showed that tamsulosin caused hyperglycemia as well as insulin resistance in both normal rats.